AT1 and AT2 Receptor Knockout Changed Osteonectin and Bone Density in Mice in Periodontal Inflammation Experimental Model

Background: The aim of this study was to evaluate the role AT1 and AT2 receptors in a periodontal inflammation experimental model. Methods: Periodontal induced by LPS/Porphyromonas gingivalis. Maxillae, femur, vertebra were scanned using Micro-CT. Maxillae analyzed histopathologically, immunohistochemically, RT-PCR. Results: showed decreased BMD H compared with WT (p < 0.05). femur increased Tb.Sp for H, p 0.01 0.05, respectively. Tb.N (WT H-AT1 H: 0.05; H-AT2 0.05) 0.01; PD linear bone loss osteoblast cells RANKL immunostaining intense 0.001). OPG PD, when weak osteocalcin significantly stronger osteonectin fibroblasts 0.01). Conclusion: receptor knockout changed density, quality number trabeculae, cells, fibroblasts.